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Allergens > Occupational

Occupational allergens

There are a great many professional allergens since there are hundreds of molecules listed as professional allergens.
 
For the immediate allergies, the most frequently mentioned ones are:

  • Meals
  • Isocyanates
  • Squama and animal dejections
  • Saw dust
  • Dust from grains
  • Metals
  • Latex

The professional allergens may be classified in 2 categories:

1. High molecular weight allergens

They include animal products (fur, feathers, dejections…), plant products (flour, natural fibres…) and more globally proteins.  The allergic reaction set off is an IgE-mediated hypersensitivity reaction.  The test for an assay of the specific IgE is performed in the patient’s serum.  Skin tests, such as prick tests, may reveal this IgE-dependent reaction.Atopy is a risk factor.

2. Low molecular weight allergens

They include metals, chemical substances (isocyanates, sulphites, persulphates…) and more globally non-protein molecules and haptens.
 
Most often, a non IgE-dependent mediated reaction is provoked.  However, certain low molecular weight allergens may be the cause of IgE-dependent hypersensitivity (platinum salts, isocyanates…). Skin tests or specific IgE may then turn out to be positive.  As opposed to high molecular weight allergens, atopy is not a factor that predisposes to sensitivity to low molecular weight allergens.
 
The diseases induced by professional allergens are most often:

Molecules in the professional environment may also trigger delayed cell hypersensitivity, thereby professional contact eczema.  The most often incriminated molecules are:

  • Metals:  nickel in metal instruments, chrome in metal instruments but also the tanning of leather, cement, cobalt found in certain cements and paints.
  • Hair products:  metals in instruments, paraphenylenediamine in dyes, ammonium persulphate in hair dyes, monothioglycolate in products for permanents, …
  • Hospital disinfectants  or ingredients in industrial cleaning products such as quaternary ammoniums, glutaraldehyde, formol, …
  • Paints, glues and resins  often sensitised by the preservatives that they contain but especially by resin monomers such as Epoxy or acrylates.
  • Plants and flowers
  • Drugs handled in a hospital or in the drug industry.
  • The components in protective clothing:  agents in the rubber vulcanising of gloves, boots and rubber glasses, chrome in the leather of safety boots.